MANCHESTER, England -- The final round of international fixtures in 2016 did no favors for managers of some of the English Premier Leagues title hopefuls.Jose Mourinho and Arsene Wenger, in particular, will vouch for that ahead of the renewal of their often-heated coaching rivalry.When Mourinhos Manchester United and Wengers Arsenal meet at Old Trafford on Saturday for the standout game in the 12th round of matches, there could be some major names missing because of injuries sustained on international duty.United captain Wayne Rooney has caused a furor by being photographed, looking bleary-eyed, alongside some guests at a wedding party taking place at the England team hotel on Saturday. But by then, hed picked up a knee injury during Englands 3-0 win over Scotland the night before, causing him to miss Tuesdays match against Spain, and Rooney is now doubtful for the Arsenal game.It was the last thing Mourinho would have wanted, considering he is already without suspended striker Zlatan Ibrahimovic and center backs Eric Bailly and Chris Smalling, as well as having serious doubts over the fitness of midfielder Marouane Fellaini and full backs Luke Shaw and Antonio Valencia.Wenger, meanwhile, will ask Alexis Sanchez for an honest assessment of his fitness after Arsenals star forward sustained a hamstring injury while away with Chile. Sanchez missed a draw against Colombia but returned for the 3-1 win over Uruguay on Tuesday, although his right leg was heavily strapped for the match.Sanchez isnt due to return to Arsenals training base until Friday and the match against United is a lunchtime kickoff on Saturday.What I will consider is the risk of injury because he played while recovering from a hamstring injury, Wenger said on Thursday. Ill consider the way he feels as well. On that front you depend on the honesty of the player, how they feel and how they recover.Wenger will be careful about overloading Sanchez, who has scored eight goals for Arsenal this season from his new position as converted striker. This time last year, Sanchez picked up a hamstring injury following a grueling run of back-to-back games for club and country and ended up missing the next two months, which proved to be a huge blow to Arsenals title hopes.Arsenal plays Paris Saint-Germain in a big Champions League game on Wednesday, too.Liverpool and Chelsea, the Premier Leagues top two, could also be counting the cost of the recent international games after injuries to key players.Adam Lallana, one of Liverpools quartet of sprightly forwards that has been in devastating form this season, hobbled off during Englands game against Spain and is a doubt for the leaders trip to Southampton.As for second-place Chelsea, Diego Costa was ruled out of both of Spains games during the break because of groin injury and Eden Hazard limped off during Belgiums 8-1 win over Estonia with an apparent calf injury. It isnt yet clear if either Costa or Hazard -- the scorers of 15 league goals between them -- will be fit for the Chelseas match at Middlesbrough.Heres what else to look out for this weekend:---CRYSTAL PALACE-MANCHESTER CITYPalace has conceded 10 goals in its last three games and hasnt kept a clean sheet in the league all season. In terms of points per game (0.73) in 2016, Alan Pardews side is the worst-performing team across Englands four leagues this calendar year.Probably, then, the last team it would want to see arriving at Selhurst Park on Saturday is Pep Guardiolas free-scoring Man City side. Star striker Sergio Aguero will be raring to go for City, having failed to start for Argentina in either of their World Cup qualifying games over the international break.---WATFORD-LEICESTERLeicester can clinch qualification to the knockout round of the Champions League on Tuesday, but its players would be wise not to look that far ahead this weekend.The Premier League champions head to Watford just two points above the relegation zone, having lost at home to West Bromwich Albion in the last game before the international break.Leicester will be boosted by leading striker Jamie Vardy ending his run of 14 games without a goal for club or country by scoring for England against Spain. Vardy scored 24 league goals last season, but has only two so far this season. Wholesale Adidas Hockey Jerseys . Traditional contenders Brazil, Greece and Turkey drew the other three spots to complete the 24-team field for this summers tournament in Spain, basketball governing body FIBA announced Saturday at its meeting in Barcelona. Cheap NHL Jerseys Authentic . "I wrote 36 on my sheet at the beginning of the game," the Cincinnati coach said, referring the yard line the ball would need to be snapped from. http://www.cheapnhljerseysusa.com/ .S. Open champion Justin Rose birdied the first hole with a blind shot he hit to a foot of the pin, and he stayed in front Tuesday until he completed a 4-under 67 for a two-shot lead over Jason Dufner in PGA Grand Slam of Golf. Cheap NHL Jerseys China . The Cleveland Indians, Tampa Bay Rays, and Texas Rangers all won on Sunday meaning the Rangers will host the Rays in a play-in game on Monday. Cheap Adidas NHL Jerseys . Shot outdoors against the stunning backdrop of Banff, Alta., the networks 30-minute original production airs tonight at 8pm et/5pm pt on TSN2. The four All-Star teams will play for $100,000 in prize money during TSNs annual skins game, airing live this weekend on TSN from The Fenlands Banff Recreation Centre. Gabby Douglas is a three-time gold medalist and has been one of the best gymnasts in the world for the past several years. A valuable member of the U.S. team, Douglas should be celebrated for her contributions to her team, sport and country for years to come.However, Douglas has had to deal with SO MUCH HATE on social media since her all-around win in 2012. From her hair to her lack of smiling to the position of her hand during the national anthem, everything she does has been criticized. The backlash has been so bad in Rio, she understandably called it hurtful and a lot to deal with?and has even tried to stay off of social media as a resultt.dddddddddddd After finishing a disappointing seventh during the uneven bars final on Sunday, its been a tough stretch for the decorated star.Despite all of the negativity, there has thankfully been an outpouring of support for Douglas from fans, fellow athletes and celebrities. Here is a small sampling below. Yup, what they said. Keep your head up, Gabby! Youll always be a champion to us.See something entertaining on social media that you think deserves to be shared? Let me know on Twitter, @darcymaine_espn. ' ' '